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  • Are Rules Really Meant to Be Broken?

    Risk managers spend a lot of time and effort promoting policies and procedures meant to improve patient safety and protect the organization from liability. But is there ever a time to condone breaking those rules?

  • Gender-Affirming Care Caught in Legal Gray Area, Liability Possible

    Healthcare organizations providing gender-affirming care — which may be defined broadly — could face consequences if they do not conform with recently imposed federal restrictions. Understanding the changes and how they affect clinical treatment is key to avoiding potentially serious regulatory violations and other liability.

  • Plasma Exchange for Relapses in MOGAD

    In this multicenter, international study of a cohort of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), the authors examined the effectiveness of plasma exchange for acute relapses and reported favorable disability outcomes but found that advanced age and delayed initiation of the treatment reduced its benefit.

  • Potential Benefit of Glyburide in Moderate-Volume Acute Ischemic Stroke

    An exploratory analysis of the CHARM trial suggests intravenous glyburide may improve outcomes in large hemispheric stroke patients with infarct volumes < 125 mL, particularly alongside thrombectomy, reducing edema, mortality, and the need for decompressive surgery, and highlighting a potential neuroprotective role.

  • Repeated Head Impacts Are Associated with Tau Astrogliopathy

    This study demonstrates that both traumatic brain injury and participation in contact sports are independently associated with increased tau astrogliopathy, particularly thorn-shaped astrocytes, even when cases of chronic traumatic encephalopathy neuropathologic change are excluded.

  • Intracranial EEG Activity and Consciousness in Frontal Lobe Seizures

    Frontal seizures were classified as focal preserved consciousness (FPC), focal impaired consciousness (FIC), or focal to bilateral tonic-clonic (FBTC). Intracranial electroencephalogram (icEEG) recording was analyzed in those seizures. FPC seizures showed significant icEEG power increases in the seizure-onset region across frequency ranges, with smaller increases in other regions. FIC seizures demonstrated a significant increase in icEEG power not only within the seizure-onset zone but also across distal cortical regions. Widespread power increases also were noted in FBTC seizures. In addition, the power increase in FBTC is much greater compared to FIC seizures.

  • Increased Treatment Opportunities for Trigeminal Autonomic Cephalalgias

    Trigeminal autonomic cephalalgias (TACs) include cluster headache, paroxysmal hemicrania, hemicrania continua, short-lasting unilateral neuralgiform headache with conjunctival injection and tearing, and short-lasting unilateral neuralgiform headache with cranial autonomic symptoms. They are female-predominant primary headache disorders that coexist with migraines and mood disorders. Indomethacin is underused in those TACs that are specifically indomethacin responsive. Noninvasive vagus nerve stimulation for TACs is well-tolerated and more effective for prevention than as an acute treatment.

  • Oral Health for the PCP: A Collaborative Approach to Patient Care

    Primary care physicians play a critical role in recognizing oral health as a sign of systemic disease. Common oral conditions can have diagnostic and preventive implications for broader health, including cardiovascular disease and autoimmune disorders. By conducting oral examinations, identifying red flags that require referral, and counseling patients on preventive care, physicians can integrate oral health awareness into comprehensive patient care.

  • Infectious Disease Updates

    Visceral Larva Migrans from Baylisascariasis; Measles Testing of Persons with HIV; Ambulatory Glucose Monitoring a Risk for Bloodborne Pathogens

  • Fleas, Typhus, and Texas

    Cases of flea-borne typhus are dramatically increasing in Texas.